We now know that the cerebrospinal fluid (CSF) of these children often shows inflammation, which is indicative of brain inflammation. The only way to reduce the morbidity of OMS and improve prognosis is to eliminate this inflammation. Routine lab testing of spinal fluid usually misses it because the total number of cells may be normal, but the proportion of inflammatory cells is increased.
Ours is the only center with experience in interpreting results in children
that offers sophisticated immunophenotyping testing on spinal fluid. The testing
must be done on freshly acquired CSF leukocytes, so it cannot be shipped,
even by courier. We use this information to select the best treatment. There
is no other way to get this information than to do a spinal tap.
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